What are Polynucleotides?
Polynucleotides are bioactive molecules, long chains of DNA fragments which are often derived from ethically sourced fish DNA. They act as biostimulators which:
- Stimulate fibroblasts to produce collagen and elastin, improving skin elasticity and firmness.
- Improve skin hydration by helping tissues retain moisture.
- Reduce fine lines, smooth skin texture, and aid natural repair mechanisms.
- Calm inflammation and help with skin damage from sun, environmental stress, or acne scarring.
Unlike Botox, polynucleotides do not add volume or change your facial shape; instead, they help restore and rejuvenate skin quality from the inside. Our polynucleotide therapy is ideal for those seeking skin renewal without dramatic changes.
All our protocols are based on the latest peer-reviewed research and adhere to strict medical standards, ensuring you receive only treatments proven to be safe and effective.
Treatment Areas
Polynucleotides can be used on many areas where skin shows signs of ageing, damage, or loss of elasticity:
- Face (fine lines, smile lines, cheeks)
- Under-eye area, dark circles, and thin/crepey skin around eyes
- Neck & décolletage
- Hands
- Areas with acne scars or uneven texture
Why Choose Oxona Healthcare for Polynucleotides in Oxford?
As a doctor-led clinic, we are committed to evidence-based medicine. Unlike beauticians or non-medical providers, our team is trained to assess your individual needs, manage any risks, and deliver treatments that are both safe and effective. We never compromise on clinical standards.
- Clinically Trained Doctors – All treatments are delivered by experienced dermatology medics who understand skin biology and safety protocols.
- Personalised Assessment & Plan – We take time during your consultation to assess your skin, discuss your goals, and determine whether polynucleotides are the right option.
- Premium Biocompatible Products – We use top-quality, ethically sourced formulations vetted for safety.
- Full Aftercare & Follow-Up – We guide you through pre-treatment preparation, post-treatment care, and maintenance, so your skin heals well and results last.
What to Expect During Treatment
- Consultation – We review your medical history, examine your skin, discuss your goals (fine lines, texture, tone, etc.), and ensure you are a suitable candidate. This medical consultation is essential to ensure your suitability for treatment and to tailor our approach to your unique skin biology—something only a qualified medical professional can provide.
- Treatment – The session generally takes around 30–45 minutes. Topical anaesthetic can be used to improve comfort. Polynucleotides are injected using fine needles into specified superficial layers of skin.
- Number of Sessions – Usually an initial course of 2–4 sessions, each spaced 2–4 weeks apart, is recommended for optimal results.
- Maintenance – After the initial course, maintenance treatments every 6–12 months, depending on skin’s condition, age, and lifestyle.
Results & Duration
Many patients see improvements in skin hydration, smoothness, and tone within 1–2 weeks after treatment. More visible changes, including improved elasticity, reduced fine lines, and improved texture will continue to develop over 3–4 weeks following the full treatment course. Results typically last 6–12 months, depending on individual factors such as skin type, lifestyle, sun exposure, and skincare habits.
Safety, Side Effects & Suitability
Your safety is our highest priority. All procedures are performed in a clinical environment, with full medical oversight and adherence to the latest evidence-based guidelines. We do not offer or endorse treatments outside the scope of medical best practice.
Polynucleotide therapy is generally well tolerated. However, as with any injectable treatment, there may be mild side effects including some redness, mild swelling, or bruising at injection sites. These often settle within 24–48 hours following your treatment.
Less common, you may need to consider if:
- You are pregnant or breastfeeding
- You have an allergy to fish or seafood proteins, or sensitivity concerns
- You are on certain medications or have skin conditions (our doctors will review this during your consultation)
We’ll give you guidance both before and after treatment to maximise comfort and any post-treatment care.
Our Locations
We offer polynucleotide treatments at our clinics in:
- Oxford
- St Albans
Each clinic provides a professional, welcoming environment equipped to deliver safe, effective care.
Book Your Polynucleotide Consultation
Ready to rejuvenate your skin from within? Book a consultation at Oxona Healthcare Oxford today. Let our dermatology doctors guide you through a tailored treatment plan so you can enjoy healthier, more luminous skin.